Women’s ownership of their sexual and reproductive health (SRH) is a rights-based expression of self-determination. In this issue of Outlook on Reproductive Health, we address these rights and highlight recent information on technologies and practices with high potential to enable and expand SRH self-care, including self-administration of injectable contraception, pericoital or "on-demand" contraception, safe practice of medical abortion at home, self-testing for HIV, and vaginal self-sampling for cervical cancer screening. The available evidence demonstrates that health systems and practitioners can and should trust women with many aspects of their own care.