This document provides a historical overview and current status of technologies that support injection safety such as autodisable (AD) syringes, reuse prevention syringes (RUP), sharps injury prevention (SIP) syringes, disposable-syringe jet injectors, and compact prefilled autodisable (CPAD). It also documents the global progress over the past two decades that have led to a significant reduction in bloodborne pathogen transmission and the continued efforts needed to sustain the gains that have been made and to eliminate disease transmission from needlestick injuries and misuse of syringes.