The Data Use Partnership (DUP) is a Tanzanian Government–led initiative that is improving the national health care system through better digital health systems and the use of health information. DUP aims to strengthen digital health and build local capacity so that everyone—from government officials to health workers to patients—can take more informed action to improve health, leading to a healthier Tanzania. Data governance refers to the process of safeguarding and harnessing digital technologies and the information they contain across the data lifecycle—from the moment a patient’s information is first entered in the system and throughout his or her entire life. This brief summarizes how Tanzania, under the DUP initiative, is working to establish strong governance structures to manage data, establish data quality, and facilitate data use to advance better health outcomes.