The World Health Organization (WHO) recommends the programmatic use of two vaccines, RTS,S/AS01 and R21/Matrix-M, for the prevention of Plasmodium falciparum malaria in children living in malaria-endemic areas—prioritizing areas of moderate and high transmission.

This fact sheet provides an overview of the development history of RTS,S, the impact of and evidence from the RTS,S pilot program conducted in Ghana, Kenya, and Malawi, and recent results from a study on the seasonal use of RTS,S.