The World Health Organization (WHO) recommends the programmatic use of two vaccines, RTS,S/AS01 and R21/Matrix-M, for the prevention of Plasmodium falciparum malaria in children living in malaria-endemic areas—prioritizing areas of moderate and high transmission.

This fact sheet provides an overview of the evidence that informed WHO to make their recommendation of R21, as well as a summary of the development history of and clinical evidence on R21.