This brief provides key data, insights, and policy recommendations to strengthen Africa’s mpox diagnostic capacity. It explores the challenges of limited testing access, the need for locally manufactured diagnostics, and the role of innovative point-of-care solutions in improving outbreak response. The information in this brief is valuable for anyone looking to support or understand efforts to expand diagnostic access through policy, research, funding, or implementation. By integrating diagnostics into national and regional health strategies, Africa can build a more resilient, prepared, and responsive health system.