PATH’s Scale-Up project seeked to reduce cervical cancer incidence through improved and expanded screening using human papillomavirus (HPV) testing. Between 2015 and 2020, PATH partnered with countries in Central America to implement HPV testing for cervical cancer screening within public sector clinics. The project demonstrated that a new model of cervical cancer screening anchored on HPV testing is achievable. This resource shares the key findings and public health implications.