Recognizing the disproportionate burden of new HIV infections faced by adolescent girls and young women (AGYW), PEPFAR and partners launched Determined, Resilient, Empowered, AIDS-free, Mentored and Safe (DREAMS), a public-private partnership designed to reduce the rate of HIV among AGYW in 10 of the highest HIV-burden countries in sub-Saharan Africa. DREAMS consists of a comprehensive core package of evidence-informed behavioral, biomedical, and structural interventions designed to prevent HIV. This brief summarizes PATH’s activities and achievements as a DREAMS implementing partner in western Kenya.