The World Health Organization recommends the programmatic use of two vaccines, RTS,S/AS01 and R21/Matrix-M, for the prevention of Plasmodium falciparum malaria in children living in malaria-endemic areas—prioritizing areas of moderate and high transmission.

More than 28 countries have expressed interest in introducing a malaria vaccine, and most are actively moving toward introduction. This fact sheet reviews the two vaccines side-by-side, to examine how the two products are similar and how they differ to aid in country decision-making.