High–quality evidence assessing single–dose HPV vaccination suggests that implementing a single–dose schedule is scientifically sound and provides the greatest public health benefit.

A single–dose HPV vaccination schedule has the potential to reach more girls and avert a greater number of cervical cancer cases than reaching fewer girls with a two–dose regimen.

This brief provides a list of frequently asked questions and answers about the evidence around single–dose HPV vaccination, and the current policy landscape.