This document is intended as a how-to implementation guide for providing oral pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) via online pharmacy service delivery (ePrEP/ePEP) based on learnings and evidence from the ePrEP Kenya pilot study that ran from October 2022 through July 2024.

The guide was developed to support ministries of health and their partners as they develop strategies for HIV prevention services—specifically, ePrEP and ePEP delivery through a telehealth and online pharmacy model. It outlines a suggested approach that can be tailored based on epidemiological, social, economic, health systems, and policy contexts. Service delivery partners should exercise flexibility and adapt these recommendations and tools to their specific contexts, available resources, and infrastructure.