One of the primary benefits of ICTs is the improved ability to collect, analyze, and use data. But to do this well and sustainably requires fostering a data use culture. In this paper, we explore two frameworks that PATH has developed to highlight the necessary components of a data use culture-at a national system or country level as well as at organization, facility, community, or individual levels. We also present recommendations for how the digital health field can take local, regional, and global action to accelerate the rate at which countries and communities are designing and building their own data use cultures.