The COVID-19 pandemic defined 2020 for PATH and for the world. As COVID-19 case numbers grew over the first half of the year and access to routine health services decreased, we knew we needed to act quickly to help protect health equity for all. The health of our communities—as well as the hard-won gains of the past several years of health advocacy—were at risk. With support from the Bill & Melinda Gates Foundation, PATH pivoted many of our planned efforts to focus on protecting essential health services and helping governments respond to the pandemic—all while keeping our goals for the future top of mind. This case study highlights some of the new tactics we took on, and lessons learned, in this unprecedented year.