Environmental enteric dysfunction (EED) is associated with serious risks for children in low-resource settings. We currently need a tool to quantitate EED biomarkers to increase the efficiency of EED screening before clinical trial enrollment. This study worked to develop an assay to detect and quantify EED biomarkers in human specimens

Author: Arndt M, Cantera J, Choy R, Tyler A, Lyman C, Boyle D

Publication date: November 2017

Region: Global

Part of series: ASTMH posters

E. coli pathotypes are among the leading causes of child diarrhea, and early enteropathogen exposure has been associated with child stunting. This study examined the frequency of pathogenic E. coli infection from birth to 6 months in Bangladesh, and identified strains associated with linear growth at 24 months.

Author: Arndt M, Pavlinac P, Richardson B, Ahmed T, Mahfuz M, Haque R, John-Stewart G, Denno D, Walson J

Publication date: November 2017

Region: Asia

Part of series: ASTMH posters

Cryptosporidium is an intestinal protozoan parasite that can cause diarrheal disease in young children. The economic burden of cryptosporidiosis has been poorly characterized. This study aimed to describe the economic impact of cryptosporidiosis on families and communities in low-resource settings, and identify data gaps to inform objectives for future analyses.

Author: Choy R, Rafferty E, Schurer J, Arndt M, de Hostos E, Shoulz D, Farag M

Publication date: November 2017

Region: Africa, Asia, Latin America

Part of series: ASTMH posters

PATH and Mountain Safety Research® Global Health co-developed the MSR SE200 Community Chlorine Maker (MSR SE200), a portable, affordable device that makes chlorine on demand with the push of a button for safe, drinkable water.

Publication date: October 2017

Region: Global

Part of series: Technology Updates

PATH and partners are developing iOWH032 as a complement to oral rehydration solution for diarrheal disease treatment. Acting via inhibition of the cystic fibrosis transmembrane conductance regulator chloride channel, iOWH032 is a novel, low-molecular-weight compound intended to reduce fluid and electrolyte loss in cases of cholera toxin-induced secretory diarrhea.

Publication date: August 2017

Region: Global

DefeatDD’s weekly blog features posts from PATH staff and partners about the burden of diarrheal disease and the solutions to defeat it, including trends in child health, success stories, news, and personal perspectives.

Publication date: 2017

Region: Global

Part of series: Blogs

DefeatDD.org is an interactive website aimed at informing and inspiring advocates committed to joining their voices and raising awareness about diarrheal disease. The website hosts a weekly blog about advances in diarrheal disease control and provides key documents and links to information on simple, lifesaving interventions that have the potential to significantly impact diarrhea incidence worldwide.

Publication date: 2017

Region: Global

Part of series: Websites

This website about PATH’s drug development program provides an overview of the program and its featured projects. See other PATH program websites.

Publication date: 2017

Region: Global

Part of series: Program websites

Host antisecretory targets are a promising treatment option for easing the symptoms of diarrheal disease and addressing shortcomings of existing therapies. This poster presentation from the American Society of Tropical Medicine and Hygiene 2016 Annual Meeting summarizes the results of tests comparing several clinical-stage drug candidates that have the potential to treat acute secretory diarrhea.

Publication date: November 2016

Region: Global

Part of series: ASTMH posters

This fact sheet highlights PATH’s work to address rotavirus, the leading cause of severe diarrheal disease. It includes general information about our efforts to increase access to and effectiveness of existing vaccines, as well as to develop new vaccines and to raise awareness through advocacy.

Publication date: August 2016

Region: Global

Part of series: Diarrheal disease fact sheets

This fact sheet describes PATH's enteric vaccine project from a technical perspective. It includes an overview of PATH's vaccine development portfolio, research activities, and partners to support the development of effective and affordable vaccines against Shigella and enterotoxigenic Escherichia coli, the leading bacterial causes of diarrhea, for children in the developing world.

Publication date: May 2016

Region: Global

Part of series: Diarrheal disease fact sheets

Part of the Technology Updates series, this fact sheet describes PATH's work, in collaboration with Cascade Designs, to develop a portable, battery-powered, easy-to-use device that delivers consistent concentrations of chlorine to treat water in low-resource settings.

Publication date: December 2015

Region: Global

Part of series: Technology Updates

This presentation outlines PATH’s work in rural Bihar, India, supporting sustainable sanitation improvements. Specifically, it illustrates the research completed from user needs assessment to design validation.

Publication date: October 2015

Region: Asia

This fact sheet provides an overview of PATH's work in protecting children from diarrheal disease.

Publication date: June 2015

Region: Global

Part of series: Areas of focus fact sheets

Infographic and video titled “Rotavirus Vaccines: Rapid Rollout is Saving Lives.”

Publication date: May 2015

Region: Global

This fact sheet provides an overview of rotavirus disease and vaccines in Tajikistan. It includes information about the tremendous burden of rotavirus diarrhea in Tajikistani children, rotavirus diarrhea treatment and prevention strategies, and the effectiveness of rotavirus vaccines.

Publication date: January 2015

Region: Asia

Part of series: Rotavirus disease and vaccines fact sheets

DefeatDD.org’s 3D News: Perspectives on Defeating Diarrheal Disease provides news and views for advocates, program implementers, policymakers, and anyone interested in the growing momentum for defeating the second-leading killer of children worldwide. The newsletter offers the latest on interventions and solutions, profiles of partners and success stories, summaries of recently published reports, upcoming events, and more.

Publication date: 2015

Region: Global

Part of series: E-newsletters

This website about PATH’s Cambodia country program provides an overview of the program and its featured projects. See other PATH program websites.

Publication date: 2015

Region: Asia

Part of series: Program websites

A Healthy Dose from PATH’s Drug Development program gives advocates, policymakers, government and agency leaders, and anyone interested in global health a quarterly update on our work. Each issue features reports from the field, news on the latest clinical trial milestones, and resources in nonprofit drug development.

Publication date: 2015

Region: Global

Part of series: E-newsletters

Published from 2007 to 2015, Vaccines for the Future provided quarterly updates on our efforts to accelerate the development of innovative, safe, effective, and affordable vaccines against pneumonia (pneumococcal disease) and diarrheal disease (rotavirus, Shigella, enterotoxigenic Escherichia coli), as well as new vaccines for the global population against influenza, meningitis, polio, and respiratory syncytial virus. It included updates on progress, partnerships, and specific activities related to these projects. This newsletter is no longer being published and has been replaced by two newsletters: Moving the Needle provides updates on our vaccine development work, and Immunization Matters focuses on our vaccine uptake and access work.

Publication date: 2015

Region: Global

Part of series: E-newsletters