This issue of Directions in Global Health profiles five PATH projects: Entre Amigas, which is reaching young adolescent girls in Nicaragua with reproductive health and life skills; the Healthy Start for a Healthy Life project, which is improving the care of newborns in Indonesia; the Ukraine TB project, which is implementing training and IEC activities to control tuberculosis; PATH's Children's Vaccine Program, which is managing medical waste in Nepal; and the Horizons program, which is influencing gender norms among young men in Brazil.