The regulation of health technologies is a critical component of every country’s public health system and ensures that high-quality, safe health technologies reach the people who need them most. To harness momentum for regulatory harmonization, the Pan-African Parliament, New Partnership for African Development, and African Union Commission spearheaded the development of the African Union Model Law on Medical Products Regulation, which guides member states and regional economic communities in harmonizing regulatory systems and providing an enabling environment for the development and scale-up of health technologies.