This issue of Directions in Global Health highlights PATH’s work over a decade to improve control of Japanese encephalitis and make an affordable vaccine from China widely available. It includes an editorial by Dr. Kathy Neuzil, who directs PATH’s Vaccine Access and Delivery Global Program. Other articles cover work to bring a rapid test for river blindness to market, use community-led videos to improve health, tackle diabetes and tuberculosis, and help public health managers with information systems.