Qualification of Standard Membrane-Feeding Assay with Plasmodium falciparum Malaria and Potential Improvements for Future Assays

Vaccines that interrupt malaria transmission are of increasing interest. A robust functional assay to measure this activity would provide a biologically relevant means of evaluating potential vaccine candidates. This article, published in PLOS ONE, aims to qualify the standard membrane-feeding assay (SMFA). SMFA is one of the few biological assays used in preclinical and early clinical development of malaria transmission-blocking vaccines, and this study strongly supports its further development and application.

Author(s): Miura K, Deng B, Tullo G, et al.

Published: 2013

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    (Located at www.plosone.org)

    Miura K, Deng B, Tullo G, et al. Qualification of Standard Membrane-Feeding Assay with Plasmodium falciparum Malaria and Potential Improvements for Future Assays. PLOS ONE. 2013.

Resource types: Peer-reviewed journal

Diseases: Malaria

Topics: Disease/vaccine specific information

Regions: Africa