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Physical Characterization and Formulation Development of a Recombinant Pneumolysoid Protein-Based Pneumococcal Vaccine

Pneumolysin is a protein toxin produced by virtually all invasive strains of S. pneumoniae and is considered an important virulence factor. It is immunogenic and has the potential to be a new vaccine antigen offering broad serotype-independent coverage protecting against pneumococcal disease. This article, published in the Journal of Pharmaceutical Sciences, provides preformulation characterization results of a recombinant pneumolysin mutant (pneumolysoid L460D), information useful for the development of a stable pneumolysin mutant-based pneumococcal vaccine. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author: Hu L, Joshi SB, Liyanage MR, et al.

Published: 2013

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(Located at onlinelibrary.wiley.com)

Citation: Hu L, Joshi SB, Liyanage MR, et al. Physical Characterization and Formulation Development of a Recombinant Pneumolysoid Protein-Based Pneumococcal Vaccine. Journal of Pharmaceutical Sciences. 2013;102(2):387-400.

Resource types: Peer-reviewed journal

Diseases/vaccines: Pneumococcus

Topics: Disease/vaccine specific information

Regions: Global