Removing the Age Restrictions for Rotavirus Vaccination: A Benefit-Risk Modeling Analysis
This article, published in PLOS Medicine, reports on a study that analyzed the benefits and risks of relaxing the vaccine dosing age restrictions for rotavirus vaccines and concluded that the lives of nearly 50,000 additional children in low- and middle-income countries can be saved. The study found that removal of the existing age restrictions—administration of the first dose at 15 weeks or earlier and the last dose at 32 weeks or earlier—in low- and middle-income countries would permit a third more children to be vaccinated, which would prevent an estimated additional 47,200 rotavirus deaths. In addition to evaluating the benefits, the study also assessed the side effects, concluding that there could be approximately 300 additional vaccine-associated intussusception deaths with a relaxation of age restrictions.
Author(s): Patel MM, Clark AD, Sanderson CFB, Tate J, Parashar UD
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Citation: Patel MM, Clark AD, Sanderson CFB, Tate J, Parashar UD. Removing the Age Restrictions for Rotavirus Vaccination: A Benefit-Risk Modeling Analysis. PLOS Medicine. 2012;9(10):e1001330.