Progress and Hurdles in the Development of Vaccines Against Enterotoxigenic Escherichia coli in Humans
This article, published in the Expert Review of Vaccines, describes the status of vaccines under development to address enterotoxigenic Escherichia coli (ETEC), which have been designed to stimulate local intestinal immunity and are delivered either orally or transcutaneously. The authors detail how newer experimental ETEC vaccine candidates are being developed with hope to provide long-lasting and more broad-based protection. Some of these candidates have shown promising results in safety and immunogenicity studies and are approaching field trials for efficacy. The authors conclude that a key problem is the development of an ETEC vaccine that is both practical and inexpensive so that it can be affordable for use in poor countries where it is most needed. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)
Author: Zhang W, Sack DA
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Citation: Zhang W, Sack DA. Progress and Hurdles in the Development of Vaccines Against Enterotoxigenic Escherichia coli in Humans. Expert Review of Vaccines. 2012;11(6):677-694.
Resource types: Peer-reviewed journal
Diseases/vaccines: Shigellosis and enterotoxigenic Escherichia coli (ETEC)