Prenatal Prevention of Respiratory Syncytial Virus Bronchiolitis
The authors of this article, published in Expert Review of Anti-infective Therapy, discuss how pregnancy may provide a unique window of opportunity for interventions aimed at preventing severe respiratory syncytial virus (RSV) infection in the newborn and young infant. In animal models, maternal RSV immunization during pregnancy increases the titer of RSV-neutralizing antibodies in the offspring and reduces viral replication. However, in humans, clinical development of preventative and therapeutic interventions during pregnancy is hampered by the unique position of pregnant women and their fetuses as research subjects. Ethically acceptable interventions that target the pregnant woman and the fetus are needed to reduce the major burden caused by RSV bronchiolitis during infancy.
Author(s): Belderbos M, Kimpen JLL, Bont L
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Citation: Belderbos M, Kimpen JLL, Bont L. Prenatal Prevention of Respiratory Syncytial Virus Bronchiolitis. Expert Review of Anti-infective Therapy. 2011;9(9):703–706.