In this article, published in the Journal of Controlled Release, the authors describe how dry-coated microprojections, a needle-free vaccine delivery device, can deliver vaccine to abundant antigen-presenting cells in the skin and induce efficient immune responses, and are expected to be thermostable at elevated temperatures. The authors were able to dramatically improve their previously reported gas-jet drying coating method and greatly increase the delivery efficiency of coating from patch to skin using an influenza vaccine. The dry-coated microprojection patches thus have key and unique attributes in ultimately meeting the medical need in certain low-resource regions with low vaccine affordability and difficulty in maintaining “cold-chain” for vaccine storage and transport. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author(s): Chen X, Fernando GJP, Crichton ML, et al.

Published: 2011

Resource types: Peer-reviewed journal

Diseases: Influenza

Topics: Disease/vaccine specific information; Cold chain logistics and technologies; Delivery technologies

Regions: Global