Vaccines With Aluminum-Containing Adjuvants: Optimizing Vaccine Efficacy and Thermal Stability

Aluminum-containing adjuvants have been in use in vaccines for decades to enhance immune responses. However, exposure of vaccines containing these adjuvants to temperatures outside of the recommended storage ranges (especially exposure to freezing temperatures) puts the vaccines at risk. This article, published in the Journal of Pharmaceutical Sciences, discusses how optimizing the stability of aluminum adjuvanted vaccines requires an understanding of the freeze sensitivity of the adjuvant and the freeze and heat sensitivity of the antigen in the presence of the adjuvant. The authors also survey the different formulation approaches that can be used to increase the stability of these vaccines, helping to improve their effectiveness. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author(s): Clapp T, Siebert P, Chen D, Jones Braun L

Published: 2010

  • Visit web page (English)

    (Located at onlinelibrary.wiley.com)

    Citation: Clapp T, Siebert P, Chen D, Jones Braun L. Vaccines With Aluminum-Containing Adjuvants: Optimizing Vaccine Efficacy and Thermal Stability. Journal of Pharmaceutical Sciences. 2011;100(2):388-401.