Slow decision-making by policymakers can contribute to a substantial lag between the availability of lifesaving interventions, such as vaccines, and developing countries’ access to them. This booklet presents a set of advocacy tips, success …

This document aims to elucidate the World Health Organization (WHO) process for developing policy guidelines for a malaria vaccine. The analysis considered past WHO recommendations on new interventions and assessed potential implications …

This article, published in Trends in Parasitology, presents the current understanding of apical membrane antigen 1 (AMA1), particularly in relation to the potential of AMA1 as a malaria vaccine and the approaches being taken toward clinical …

This study, published in the New England Journal of Medicine, compares the efficacies of two treatments--oral artesunate and artesunate followed by mefloquine--for uncomplicated falciparum malaria in Pailin, western Cambodia, and Wang Pha, …

This graphic displays the malaria parasite's life cycle and highlights where three different types of vaccines could interrupt various stages of the life cycle.

This article, published in Nature Medicine, reviews current successful vaccines and identifies their mechanisms of protection in the hopes of tackling the challenges posed by those infectious targets that have thus far escaped successful …

Highly sensitive and reliable assays based on the quantitation of immunologically relevant component(s) in recombinant or whole parasite-based vaccines would facilitate pre-clinical and clinical phases and the monitoring of malaria vaccine …

This fact sheet provides an overview of the development and testing of malaria vaccine candidates through clinical trials, including an explanation of why trials are important and descriptions of each clinical trial phase.

Malaria is a leading cause of morbidity and mortality in children younger than 5 years in Kenya. Within the context of planning for a vaccine to be used alongside existing malaria control methods, this study, published in Malaria …

Malaria is a leading cause of mortality and morbidity in Mozambique, with nearly three-quarters of the country’s malaria-related deaths occurring in children younger than five years. A malaria vaccine is not yet available, but planning is …

This web page provides frequently updated information about current disease outbreaks, as well as disease-specific archives of past alerts and links to related resources.

This study, published in the New England Journal of Medicine, evaluated the efficacy of the RTS,S malaria vaccine given with a more immunogenic adjuvant system (AS01E) than one used in a previous study (AS02A). The study was conducted in …

This fact sheet describes PATH's work in malaria control and prevention, including its work under the Malaria Control and Evaluation Partnership in Africa and the PATH Malaria Vaccine Initiative.

A malaria vaccine, deployed in combination with current malaria-control tools, could play an important role in future control and eventual elimination of malaria in Africa. This article, published in the New England Journal of Medicine (NEJM), …

The Global Malaria Action Plan is a framework for action that presents (i) a comprehensive overview of the global malaria landscape, (ii) an evidence-based approach to deliver effective prevention and treatment to all people at risk, and …

This editorial, published in the New England Journal of Medicine, discusses the RTS,S vaccine against malaria and the significance of this being the first malaria vaccine to reach an advanced stage of development.

This fact sheet outlines PATH's work on vaccines and immunization. Topic areas include developing affordable vaccines, designing innovative vaccine technologies, and expanding uptake of existing vaccines. These efforts reduce the burden of malaria, …

This fact sheet provides an overview of PATH's work to develop and deliver innovative health solutions for those who need them most. These solutions range from developing and introducing affordable, appropriate technologies to creating conditions …

This commentary, published in Nature Medicine, reviews current trends that may affect whether the most promising of the 350 vaccine candidates under development will eventually be used in programs for the poor in developing countries. It also …

This comprehensive report includes expert articles on a variety of vaccine-related topics and updates on vaccine research for specific infectious diseases, such as influenza, malaria, respiratory syncytial virus, and rotavirus.

This landscape analysis identifies trends in the availability of vaccines and novel vaccine delivery technologies that are and will be of relevance to low- and middle-income countries from the present through 2025.

Malaria is preventable and treatable, but to eliminate it requires political commitment, financial support, and a higher level of local ownership than ever before. This website is a resource for the global malaria community to provide updates on the …

This web page provides information on malaria, including disease burden and vaccines, as well as links to relevent malaria resources.

This review, published in the Journal of Clinical Investigation, discusses the need to make new drugs, vaccines, and insecticides, as well as improved surveillance methods, research priorities for malaria control.

As the development of malaria vaccines accelerates, work is also underway on the policy front to pave the way for decisions on possible malaria vaccine use. Early planning is crucial to the successful adoption and introduction of a vaccine. To …