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Disease: Malaria

Total results with these characteristics: 54

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10 Tips for Successful Malaria Vaccine Advocacy

Slow decision-making by policymakers can contribute to a substantial lag between the availability of lifesaving interventions, such as vaccines, and developing countries’ access to them. This booklet presents a set of advocacy tips, success …

Author: PATH

Published: 2012

Analysis of World Health Organization Policy Development Processes for a New Intervention: Malaria Vaccines

This document aims to elucidate the World Health Organization (WHO) process for developing policy guidelines for a malaria vaccine. The analysis considered past WHO recommendations on new interventions and assessed potential implications …

Author: PATH

Published: 2008

Apical Membrane Antigen 1: A Malaria Vaccine Candidate in Review

This article, published in Trends in Parasitology, presents the current understanding of apical membrane antigen 1 (AMA1), particularly in relation to the potential of AMA1 as a malaria vaccine and the approaches being taken toward clinical …

Author: Remarque EJ, Faber BW, Kocken CH, Thomas AW

Published: 2008

Artemisinin Resistance in Plasmodium falciparum Malaria

This study, published in the New England Journal of Medicine, compares the efficacies of two treatments--oral artesunate and artesunate followed by mefloquine--for uncomplicated falciparum malaria in Pailin, western Cambodia, and Wang Pha, …

Author: Dondorp AM, Nosten F, Yi P, et al.

Published: 2009

Breaking the Cycle With Vaccines: The Malaria Life Cycle

This graphic displays the malaria parasite's life cycle and highlights where three different types of vaccines could interrupt various stages of the life cycle.

Author: PATH

Can Successful Vaccines Teach Us How to Induce Efficient Protective Immune Responses?

This article, published in Nature Medicine, reviews current successful vaccines and identifies their mechanisms of protection in the hopes of tackling the challenges posed by those infectious targets that have thus far escaped successful …

Author: Lambert PH, Liu M, Siegrist CA

Published: 2005

A Chemiluminescent-Western Blot Assay for Quantitative Detection of Plasmodium falciparum Circumsporozoite Protein

Highly sensitive and reliable assays based on the quantitation of immunologically relevant component(s) in recombinant or whole parasite-based vaccines would facilitate pre-clinical and clinical phases and the monitoring of malaria vaccine …

Author: Kumar S, Zheng H, Sangweme DT, et al.

Published: 2013

Clinical Trials: Steps in Malaria Vaccine Development

This fact sheet provides an overview of the development and testing of malaria vaccine candidates through clinical trials, including an explanation of why trials are important and descriptions of each clinical trial phase.

Author: PATH

Published: 2009

Community Perceptions of Malaria and Vaccines in the South Coast and Busia Regions of Kenya

Malaria is a leading cause of morbidity and mortality in children younger than 5 years in Kenya. Within the context of planning for a vaccine to be used alongside existing malaria control methods, this study, published in Malaria …

Author: Ba-Nguz A, Bingham A, Collymore Y, et al.

Published: 2011

Community Perceptions of Malaria and Vaccines in Two Districts of Mozambique

Malaria is a leading cause of mortality and morbidity in Mozambique, with nearly three-quarters of the country’s malaria-related deaths occurring in children younger than five years. A malaria vaccine is not yet available, but planning is …

Author: Bingham A, Gaspar F, Lancaster K, Conjera J, Collymore Y, Ba-Nguz A

Published: 2012

Disease Outbreak News

This web page provides frequently updated information about current disease outbreaks, as well as disease-specific archives of past alerts and links to related resources.

Author: World Health Organization

Efficacy of RTS,S/AS01E Vaccine Against Malaria in Children 5 to 17 Months of Age

This study, published in the New England Journal of Medicine, evaluated the efficacy of the RTS,S malaria vaccine given with a more immunogenic adjuvant system (AS01E) than one used in a previous study (AS02A). The study was conducted in …

Author: Bejon P, Lusingu J, Olotu A, et al.

Published: 2008

Fighting Malaria Today and Tomorrow

This fact sheet describes PATH's work in malaria control and prevention, including its work under the Malaria Control and Evaluation Partnership in Africa and the PATH Malaria Vaccine Initiative.

Author: PATH

Published: 2012

First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children

A malaria vaccine, deployed in combination with current malaria-control tools, could play an important role in future control and eventual elimination of malaria in Africa. This article, published in the New England Journal of Medicine (NEJM), …

Author: The RTS,S Clinical Trials Partnership

Published: 2011

From Pipeline to Product: Malaria R&D Funding Needs Into the Next Decade

This report serves as a tool to guide policymakers’ investment in new tools to control malaria, contain emerging threats, and move toward the goal of eradicating malaria from the world. It looks at the estimated funding needed for Research & …

Author: PATH

Published: 2013

The Global Malaria Action Plan for a Malaria-Free World

The Global Malaria Action Plan is a framework for action that presents (i) a comprehensive overview of the global malaria landscape, (ii) an evidence-based approach to deliver effective prevention and treatment to all people at risk, and …

Author: Roll Back Malaria Partnership

Published: 2008

A Hopeful Beginning for Malaria Vaccines

This editorial, published in the New England Journal of Medicine, discusses the RTS,S vaccine against malaria and the significance of this being the first malaria vaccine to reach an advanced stage of development.

Author: Collins WE, Barnwell JW

Published: 2008

Increasing Access to Lifesaving Vaccines: PATH Closes the Immunization Gap Through Innovation and Collaboration

This fact sheet outlines PATH's work on vaccines and immunization. Topic areas include developing affordable vaccines, designing innovative vaccine technologies, and expanding uptake of existing vaccines. These efforts reduce the burden of malaria, …

Author: PATH

Published: 2013

Innovating to Improve Health: PATH Develops and Delivers Novel Solutions for Those Who Need Them Most

This fact sheet provides an overview of PATH's work to develop and deliver innovative health solutions for those who need them most. These solutions range from developing and introducing affordable, appropriate technologies to creating conditions …

Author: PATH

Published: 2012

Introducing New Vaccines Into Developing Countries: Obstacles, Opportunities, and Complexities

This commentary, published in Nature Medicine, reviews current trends that may affect whether the most promising of the 350 vaccine candidates under development will eventually be used in programs for the poor in developing countries. It also …

Author: Clemens J, Jodar L

Published: 2005

Jordan Report: Accelerated Development of Vaccines 2012

This comprehensive report includes expert articles on a variety of vaccine-related topics and updates on vaccine research for specific infectious diseases, such as influenza, malaria, respiratory syncytial virus, and rotavirus.

Author: US National Institute of Allergy and Infectious Diseases

Published: 2012

Landscape Analysis: Trends in Vaccine Availability and Novel Vaccine Delivery Technologies: 2008–2025

This landscape analysis identifies trends in the availability of vaccines and novel vaccine delivery technologies that are and will be of relevance to low- and middle-income countries from the present through 2025.

Author: PATH, World Health Organization

Published: 2008

Making Malaria History

Malaria is preventable and treatable, but to eliminate it requires political commitment, financial support, and a higher level of local ownership than ever before. This website is a resource for the global malaria community to provide updates on the …

Author: PATH

Malaria

This web page provides information on malaria as well as links to relevant malaria resources.

Author: World Health Organization

Malaria: Progress, Perils, and Prospects for Eradication

This review, published in the Journal of Clinical Investigation, discusses the need to make new drugs, vaccines, and insecticides, as well as improved surveillance methods, research priorities for malaria control.

Author: Greenwood BM, Fidock DA, Kyle DE, et al.

Published: 2008

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