Outbreaks of highly pathogenic avian influenza are occurring in domestic fowl in many countries, posing a considerable human public health risk. The guidelines outlined in this report are the first attempt to provide comprehensive recommendations to help Georgian health workers promptly identify, report, confirm, and classify potential cases of avian influenza in humans; analyze data; investigate and respond to cases and outbreaks; and improve other aspects of an early warning system for humans. They are most appropriate for the current stage of pandemic preparedness (phases 3 to 4 of the World Health Organization [WHO] Pandemic Alert Period) and designed primarily for health personnel working at rayon and regional public health centers. In addition to general recommendations for the human avian influenza surveillance system as a whole, the guidelines include specific sections devoted to communication with the public as well as infection control in health facilities.